寻常性银屑病血清MCP-1的检测  

The Level of MCP-1 in Serum from Psoriasis Vulgaris

作　　者：唐玲[1] 于益芝[2] 李泉[1] 郭志丽[1] 阎明[1] 郑茂荣[1] 

机构地区：[1]第二军医大学附属长海医院皮肤科,上海200433 [2]第二军医大学免疫学研究所,上海200433

出　　处：《中国皮肤性病学杂志》2003年第2期87-87,90,共2页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金 (39970 689) ;上海市科技启明星计划资助 (99QB1 4 0 4 7)

摘　　要：目的　初步探讨单核细胞趋化因子 1(monocytechemoattractantprotein 1,MCP 1)在银屑病发病机制中的作用。方法　分离处于不同病期的寻常性银屑病患者外周血血清 ,通过酶联免疫吸附 (ELISA)法检测银屑病患者血清中MCP 1的水平 ;同时比较了不同病期中血清MCP 1水平。结果　银屑病患者血清中MCP 1水平明显高于健康对照组 ,但MCP 1的水平并不随病期的变化而变化。结论　银屑病外周血MCP 1的高表达可能与银屑病的发病有关。Objective To investigate the effects of MCP-1 in the pathogenesis of psoriasis.Methods The concentration of MCP-1 in the serum from psoriasis vulgaris was determined by ELISA and the levels of MCP-1 between the different stages of disease were compared.Results The concentration of MCP-1 in the serum from psoriatic peripheral blood was significantly increased.But the levels of MCP-1 did not change along with the development of disease.Conclusion High levels of MCP-1 in peripheral blood might be related to the pathogenesis of psoriasis.

关 键 词：寻常性银屑病 血清 MCP-1 检测 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]