甲磺酸左氧氟沙星对耐青霉素肺炎链球菌的体外抗菌活性  

In vitro antibacterial activity of levofloxacin against penicillin-resistant Streptococcus pneumoniae

作　　者：于亮[1] 李秀春[1] 曹文华[1] 王靖[1] 王梅[2] 

机构地区：[1]泰山医学院附属医院,泰安271000 [2]泰安市中心医院,泰安271000

出　　处：《中国抗生素杂志》2003年第4期240-241,共2页Chinese Journal of Antibiotics

摘　　要：目的　观察甲磺酸左氧氟沙星对耐青霉素肺炎链球菌 (PRSP)的药敏及疗效。方法　对 6株临床分离的耐青霉素肺炎链球菌 ,采用E test方法 ,测定甲磺酸左氧氟沙星等 6种抗生素的抗菌活性。同时观察甲磺酸左氧氟沙星单药治疗PRSP临床疗效及不良反应。结果　 6株PRSP均为低耐药菌株 ,对甲磺酸左氧氟沙星敏感。 6例患者经治疗后 ,5例痊愈 ,1例显效 ,无明显副反应发生。结论　甲磺酸左氧氟沙星可有效治疗耐青霉素肺炎链球菌性肺炎。Objective To investigate the antibacterial activity and clinical efficacy of levofloxacin against pencillin-resistant Streptococcus pneumoniae (PRSP). Methods E-test was used to examine the antibacterial activity of levofloxacin and others 5 antibiotics. The side effect and clinical efficacy were estimated after the patients were treated by levofloxacin. Results All 6 patients infected with PRSP were treated successfully by levofloxacin, 6 PRSP strains were susceptible to levofloxacin. Conclusion Levofloxacin could treat the PRSP infection effectively.

关 键 词：左氧氟沙星 耐青霉素肺炎链球菌 体外抗菌活性 药敏试验 疗效 甲磺酸左氧氟沙星 

分 类 号：R378.12[医药卫生—病原生物学] R978.1[医药卫生—基础医学]