子宫内膜异位症患者子宫内膜人白细胞抗原的免疫组化研究  

Immunohistochemical Study of Human Leucocyte Antigen in Endometrial Tissue of Patients with Endometriosis

作　　者：刘义[1] 罗丽兰[2] 赵海波[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院妇产科,武汉430022 [2]华中科技大学同济医学院附属同济医院妇产科,武汉430030

出　　处：《华中科技大学学报（医学版）》2003年第2期200-202,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：湖北省自然科学基金资助项目 (95 J4 3)

摘　　要：目的　研究子宫内膜异位症 (内异症 )患者在位和异位子宫内膜人白细胞抗原 HL A- DR的表达。方法　采用酶标链霉亲合素 -生物素 (L SAB)技术对 19例内异症不孕患者在位和异位子宫内膜腺细胞 HL A- DR抗原的表达进行免疫组化研究 ,以 19例非子宫内膜异位症的不孕患者作为对照。结果　内异症患者在位和异位子宫内膜腺细胞HL A- DR抗原的表达较对照组明显增强 (P<0 .0 1)。结论　子宫内膜 HL A-Objective To study the expression of human leucocyte antigen (HLA DR) in eutopic and ectopic endometrium in patients with endometriosis. Methods The expression of HLA DR antigen in eutopic and ectopic endometria of 19 infertile patients with endometriosis was analyzed immunohistochemically by labelled streptavidin biotin (LSAB) method. The endometria of 19 infertile patients without endometriosis was studied as controls. Results The expression of HLA DR antigen in the glandular cells in both eutopic and ectopic endometria was increased significantly as compared with that in the controls. Conclusion It is likely that aberrant expression of HLA DR antigen in endometriotic tissue is involved in the abnormal immunogenesis of endometriosis.

关 键 词：子宫内膜异位症 HLA-DR抗原 酶标链霉亲合素-生物素技术 免疫组织化学 

分 类 号：R711.71[医药卫生—妇产科学]