肺炎衣原体在急性冠状动脉综合征中的意义及其致病机制  

Significance and mechanism of chlamydia pneumoniae infection in patients with acute coronary syndrome

作　　者：焦云根[1] 祝宝华[1] 何黎民[1] 凤以良[1] 

机构地区：[1]江苏省扬州市第一人民医院心内科暨心血管病研究所,225001

出　　处：《中国综合临床》2003年第5期410-411,共2页Clinical Medicine of China

摘　　要：目的探讨肺炎衣原体 (Cpn)在急性冠状动脉综合征 (ACS)中的意义及其可能的致病机制。方法对 86例冠心病 (CHD)患者包括急性冠状动脉综合征患者 (A组 ,55例 )和症状稳定患者 (B组 ,31例 )与非CHD患者 (对照组 ,2 6例 )进行外周血Cpn特异性抗体IgG、肿瘤坏死因子 (TNF α)、C 反应蛋白 (CRP)水平检测及白细胞和中性粒细胞计数。 结果 3组Cpn特异性IgG抗体 ,阳性率分别为78.1 8%、54 .84%和 42 .30 % ;Cpn IgG阳性率、CRP、TNF α、白细胞与中性粒细胞计数 ,A组均高于B组和对照组 (P <0 .0 1 ) ,但B组与对照组差异无显著意义 (P >0 .0 5)。A组急性心肌梗死患者CRP、TNF的均值高于不稳定型心绞痛患者 (P <0 .0 5)。结论Cpn的感染与激活在ACS的发展中具有一定意义 ,其致病机制与急性炎症反应有关。Objective To study the significance and the possible mechanism of chlamydia pneumoniae infection in patients with acute coronary syndrome(ACS). Methods Cpn-IgG, tumor necrosis factor-a(TNF-a), C-reactive protein(CRP), white blood count and neutrophil(N) were detected in 86 patients with coronary heart diseases(CHD) including 55 patients with(ACS)(group A) and 31 patients with stable symptom(group B) and 26 patients without CHD(control group). Results In the three groups, the positive rates of Cpn specific IgG antibody were 78.18%, 54.84% and 42.30%, respectively. The positive rates of Cpn-IgG, CRP, TNF-a, WBC and N were higher in group A than in group B and control group(P<0.01), but there was no significance between group B and control group(P>0.05). CRP and TNF in group A with acute myocardial infarction were higher than that of the patients with unstable angina pectoris(P<0.05). Results The infection and activation of Cpn is meaningful to the development of ACS, which mechanism is related to acute inflammation.

关 键 词：冠状动脉综合征 肺炎衣原体 致病机制 C-反应蛋白 胖瘤坏死因子-α 中性粒细胞 

分 类 号：R541.4[医药卫生—心血管疾病] R518[医药卫生—内科学]