冠脉重建术后患者康复运动对ET-1、NO和CGRP的影响  

Effect of exercise training on ET-1, NO and CGRP blood concentration in patients with CAD after CABC/PICA/

作　　者：郭兰[1] 李河 孙家珍[1] 冯建章[1] 汪萍[1] 吴桂兰[1] 陈纪言[1] 周颖玲[1] 靳利军[1] 张国林[1] 刘智[1] 

机构地区：[1]广东省心血管病研究所,广东广州510080

出　　处：《心血管康复医学杂志》2003年第2期99-101,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察康复运动治疗对冠心病患者冠脉重建术后内皮素(ET-1)、一氧化氮(NO)及降钙素基因相关肽(CGRP)水平的影响,以进一步探讨康复运动治疗对冠心病患者内皮功能的作用。方法:选择56例经皮冠状动脉腔内成形术(PTCA),10例冠脉搭桥术(CABG)后患者,按随机原则此66例患者被分配入康复运动治疗组和常规治疗组,每组33例。两组临床特征无统计学差异,有可比性。两组患者均给予相同的常规药物治疗,康复运动治疗组还接受12周康复运动治疗。观察疗程前后两组ET-1、NO及CGRP基因相关肽水平的变化。结果:康复运动治疗组12周疗程前、后ET-1、NO及CGRP水平均有显著性差异(P<0.05)。治疗后康复运动组与常规治疗组的ET-1、NO、CGRP水平均有显著性差异(P<0.05)。而常规治疗组疗程前、后ET-1、NO、CGRP水平均无显著性差异(P>0.05)。结论:康复运动治疗可以改善冠心病冠脉重建术后患者的血管内皮功能。Objective: To investigate the effect of exercise training on endothelins (ET-1), nitrogen monoxide (NO) and calcitonin-gene-related peptide (CGRP) blood concentration in patients with coronary artery disease (CAD) after CABG/PTCA, and explore the relationship between cardiac rehabilitation exercise training and cardiovascular endothelial function. Methods: A total of 66 patients with CAD after PTCA/CABG were enrolled in the study. They were randomly divided into rehabilitation exercise training group and conventional care group. The patients of exercise training group got 12 weeks of exercise training and conventional care. The exercise program provided supervised conditioning for patients in rehabilitation department. The conventional group only had conventional care. The Plasm ET-1, CGRP and NO concentrations were examined at baseline and after 12 weeks of treatment from all patients. Results: After exercise training the ET-1 level decreased, NO and CGRP level increased (P<0. 05 all) in exercise training group. There were significantly differences (P<0. 05) in ET-1 ,NO and CGRP level between exercise training group and conventional care group after 12 weeks. The ET-1, NO and CGRP levels were no significantly differences (P>0. 05) after 12 weeks care in conventional care group. Conclusion: The rehabilitation exercise training can improve endothelium function in patient with CAD.

关 键 词：冠脉重建术 术后 康复运动 ET-l NO CGRP 冠心病 内皮功能 一氧化氮 内皮素 

分 类 号：R654.2[医药卫生—外科学]