曲尼司特的抗纤维化作用  

Anti-fibrosis Effect of Tranilast

作　　者：殷凯生[1] 唐瀚满[2] 

机构地区：[1]江苏省人民医院呼吸科,江苏南京210024 [2]中国药科大学制药有限公司,江苏南京210009

出　　处：《药学进展》2003年第2期114-117,共4页Progress in Pharmaceutical Sciences

摘　　要：近年来 ,实验和临床研究表明曲尼司特具有抗纤维化作用 ,它是通过阻止增生成纤维细胞释放TGF β、调节其胶原合成而发挥疗效。本文综述曲尼司特在眼科、心肾血管系统、皮肤科等方面的抗纤维化实验研究和临床应用 。Tranilast has been found to have an anti-fibrosis eff ect in the experiment and clinical application of recent years, which exerted th e effect through inhib iting fibroblast from releasing TGF-β and adjusting the collagen synthesis. Th e anti-fibrosis effect of tranilast in experimental researc h and clinical application on ophthalmology, cardionephric system, dermatology, a nd so on was summarized. It was suggested that Tranilast would be a good drug in treatment fibrous disease.

关 键 词：曲尼司特 抗变态反应药物 抗纤维化作用 实验研究 玻璃体视网膜增殖 心肾血管系统 瘢痕瘤 临床治疗 

分 类 号：R96[医药卫生—药理学]