慢性乙型肝炎肝纤维化肝血瘀阻与病理关系的探讨  

DISCUSSION ON THE RELATIONSHIP BETWEEN THE DEGREE OF LIVER-BLOODSTASIS AND THE PATHOLOGICAL STAGE OF FIBROSIS

作　　者：王宝珍[1] 刘成[2] 

机构地区：[1]上海市杨浦区卫生局,上海200092 [2]上海市曙光医院,上海200021

出　　处：《中国中医药科技》2003年第2期65-66,共2页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的 :探讨慢性乙型肝炎肝纤维化肝血瘀阻与病理的关系。方法 :将 13 5例慢性乙型肝炎有肝纤维化的患者分为血瘀组和非血瘀组 ,在分析病理与纤维化血清学指标关系的基础上 ,进一步分析肝血瘀阻与病理纤维化分期及血清纤维化指标的关系。结果 :不同纤维化分期之间血清HA、IV -C、PⅢNP的含量有显著差异 ,LN含量无明显差异。 88 1%的慢性乙型肝炎肝纤维化患者存有不同程度的血瘀表现。血瘀组患者肝纤维化病理学的变化明显重于非血瘀组 ,血清纤维化指标也呈现一致的结果 ;肝纤维化各期血瘀程度存在明显的差异 ;血瘀程度越明显则肝纤维化的程度越严重。结论 :肝脏纤维组织生成是慢性肝炎、肝纤维化患者血瘀的病理学基础 ,临床上血瘀表现的轻重 ,一定程度上反映肝纤维化的程度。Objective:To explore initially the relationship between the degree of liver-blood stasis and the pathological fibroc stage in patients with chronic hepatitis B and liver fibrosis.Method:149 patients with chronic hepatitis B were chosen according to pathology and serology diagnosis,and 135 patients were accompany with liver fibrosis,the scores of the degree of liver-blood stasis was counted according to clinical symptoms and physical signs.Analyzing the relationship between the degree of liver-blood stasis and the pathological stage of fibrosis and serum fibrosis indexes.Result:There existed significant difference between the degree of liver-blood stasis and the pathological fibroc stage and the content of HA PⅢP in serum.The histological fibroic stages became severer with the progress of degree of liver-blood stasis.Conclusion:Liver fibrosis is the fundamamental pathologic change of liver-blood stasis in patients with chronic hepatitis B and liver fibrosis.

关 键 词：肝纤维化 病理学 肝血瘀阻 乙型肝炎 透明质酸 血液 层粘蛋白 血液胶原IV 

分 类 号：R259.1[医药卫生—中西医结合]