枳实消痞丸方及其拆方对大鼠胃排空及血浆胃动素的影响  

Effect of the recipe of Zhishi Xaopi pill and it's ingredients on Gastric Emptying rate & plasma Motilin level in Rats

作　　者：窦丹波[1,2] 王松坡[1,2] 蔡金淦 唐静芬[1,2] 林江 

机构地区：[1]上海中医药大学附属曙光医院内科,200021 [2]上海市第一人民医院中医科,200080

出　　处：《现代消化及介入诊疗》2002年第2期33-35,共3页Modern Interventional Diagnosis and Treatment in Gastroenterology

摘　　要：目的研究枳实消痞丸及其拆方和不同剂型对大鼠胃排空及血浆胃动素(MOT)水平的影响.方法大鼠分为标准组、正常对照组、西沙必利组、枳实消痞丸方饮片组(全方)、消法组、补法组、和法组、全方合煎冲剂组、全方分煎冲剂,共九组,分别用生理盐水及各组药物灌胃4周后利用蛋白胨法测定胃排空;另分5组,放免法测定血浆胃动素水平。结果除和法组外,各用药组的胃排空率均显著快于正常对照组(P<0.001,0.05)而补法组和分煎冲剂组胃排空率又较全方组及西沙必利组为慢(P<0.05),其余各组两两间无显著差异.枞实消痞丸方具有促进MOT释放的作用,拆方研究表明方中消法组的药物起主要作用(P<0.05).结论枳实消痞丸方能显著促进大鼠胃排空及提高其血浆胃动素水平,拆方研究表明其中的消法组药物(枳实、厚朴、麦芽)可能起主要作用。未能发现冲剂和水煎剂之间的作用差别。但分煎冲剂作用较弱.Object:To investigate the influence of the recipe of Zhishi Xiaopi pill(ZSXPP) & it's ingredients on gastric emptying and plasma motilin(MOT)level in rats.Methods: After the rats were douched by different herbs,cisapride or normal saline in different groups for 4 weeks,the gastric emptying rate & plasma MOT level were measured separately.Results:The gastric emptying rate and plasma motilin levels were both incerased significantly by the total recipe of ZSXPP and some parts of the recipe. Conclusion: Zhishi Xizo Pi Pill can increase the gastric emptying rate and plasma motilin levels in rats;the herbs, which can remove food and qi stagnancy and relieve flatulence, including Zhishi, Houpu and Maiya, were the main effective ingredients in this recipe.

关 键 词：胃排空 胃动素 枳实消痞丸 中药 药理 

分 类 号：R285.5[医药卫生—中药学]