外周血单个核细胞中TTV—DNA检测及意义  

Significance of Transfusion Transmittde Virus(TTV) in PBMC

作　　者：李佩华 张静 

机构地区：[1]汝南县人民医院,河南汝南463300 [2]驻马店市中心血站,河南驻马店463000

出　　处：《河南预防医学杂志》2002年第6期324-325,共2页Henan Journal of Preventive Medicine

摘　　要：目的　探讨外周血单个核细胞 (PBMC)中输血传播病毒 (TTV)的检测意义。方法　采用聚合酶链反应 (PCR)方法检测 4 9例血液透析患者血清及PBMC中TTV -DNA。结果　血液透析患者TTV感染率 18.4 % (9 4 9)。PBMC中TTV -DNA检出率 2 2 .4 % (11 4 9) ,PBMC中TTV -DNA检出率在血清TTV -DNA阳性者 (6 6 .7% ) ,高于血清TTV -DNA阴性者 (12 .5 % ) (P <0 .0 5 )。结论　PBMC中TTV -DNA主要在血清阳性患者中检出 。Objection:The aim is to study the significance of transfusion transmitted virus (TTV)in perirheral blood mononuclear cell(PBMC),Methods:sera and PBMC of 49hemodialysis were detctde TTV DNA by polymerase chain reaction(PCR).Results:Infected rate of TTV in hemodialysis patients was 18.4%,Positive rate of TTV-DNA in PBMC was 22.4%,It was higher in TTV-DNA positive patients (66.7%)than negative patients (12.5%),The difference between them was significant (P<0.05).Conclusions:TTV-DNA in PBMC was seen more in TTV-DNA positive sera parients.PBMC might be a reservoir for TTV.

关 键 词：外周血单个核细胞 TT病毒 输血 TTV-DNA 血液透析 

分 类 号：R511[医药卫生—内科学]