HIV感染与HLAⅠ类基因相关性的研究  

Studies of potential linkage between HLA class Ⅰ alleles and HIV infection

作　　者：孙峥嵘[1] 尚红[1] 张远志[2] 姜拥军[1] 周立平[1] 王亚男[1] 文小宁[1] 

机构地区：[1]中国医科大学附属第一医院艾滋病研究室,沈阳110001 [2]新疆维吾尔自治区卫生防疫站

出　　处：《中华微生物学和免疫学杂志》2003年第3期222-224,共3页Chinese Journal of Microbiology and Immunology

基　　金：国家重大基础研究规划 973资助项目 (G19990 5 410 7)

摘　　要：目的　研究HIV感染与HLAⅠ类基因相关性 ,分析HLAⅠ类基因与HIV易感性及HIV感染者疾病进程的关系。方法　应用聚合酶链反应 序列特异性引物技术 (PCR SSP)检测 2 9例HIV感染者HLAⅠ类等位基因的特异性 ,从而确定HIV感染者的HLA分型。结果　在 2 9例HIV感染者中 ,HLA B35的等位基因频率较对照组明显增高 (B35 :Pc<0 .0 5 ,RR =5 .83)。结论　HIV感染者HLA B35的等位基因频率明显高于正常人 ,可能与HIV感染的易感性有关。Objective To investigate the association of HIV infection with frequencies of HLA class A, B, C alleles, and to analyze the correlation of HLA with susceptibility of HIV infection and with disease progression. Methods HLA class Ⅰ alleles was performed by Micro SSP TM , twenty-nine patients with HIV were detected. Results Analysis of the frequencies of specific at the A, B, and C loci revealed a significantly higher frequency of B35 alleles among HIV infectious patients comparing with controls (B35: P c<0.05, RR=5.83). Conclusion HLA-B35 alleles were significantly higher than that in control group, HLA-B35 alleles are potentially associated with susceptible HIV infection. [

关 键 词：HIV HLA等位基因 聚合酶链反应-序列特异性引物技术 

分 类 号：R512.91[医药卫生—内科学]