丙酸睾丸酮治疗不稳定型心绞痛临床研究  

A Clinic Study of Testosterone Propionate Treatmemt in Patients With Unstable Angina

作　　者：马建芳[1] 曾爱萍[2] 谢德辉[1] 邱凤英[1] 张宁[1] 陈宏[1] 

机构地区：[1]中国人民解放军第476医院,福州350002 [2]中国人民解放军第454医院,南京210002

出　　处：《中国工程科学》2003年第4期70-72,共3页Strategic Study of CAE

摘　　要：研究了丙酸睾丸酮治疗不稳定型心绞痛的疗效 ,给 4 8例不稳定型心绞痛患者加用丙酸睾丸酮 5 0mg肌肉注射 ,每周 2次 ,12周后观察临床疗效及血液指标变化 ,并与对照组比较。结果显示治疗组显效 32例 ,有效 14例 ,无效 2例 ,总有效率 95 84 % ,与对照组比较有显著差异 (P <0 0 1)。治疗组治疗后血清总胆固醇(TC)、低密度脂蛋白 (LDL)、C -反应蛋白 (CRP)明显下降 ,甘油三酯 (TG)轻度下降 ,高密度脂蛋白胆固醇 (HDL -C)轻度升高 ,对照组无明显变化。认为丙酸睾丸酮具有调脂、减少炎症反应及扩血管作用 。To investigate effects of testosterone propionate on patients with unstable angina, testosterone propionate (50mg, im) was given to 48 patients with unstable angina (test group), twice a week for 12 weeks. A group of patients with unstable angina were treated conventionally as a control. Clinical symptoms were evaluated and level of blood biochemistry was monitored before and after treatment. A dramatic improvement in clinical symptoms was observed in 46 out of 48 patients (96 %) in the test group, demonstrating significant differences between the test and the control group ( P <0 01). In addition, the level of TC, LDL, CRP and TG reduced significantly and HDL-C increased slightly in the test group. However, no such changes were observed in the control group. A conclusion can be drawn that testosterone propionate can significantly improve clinical symptoms and blood biochemistry level in the patients with unstable angina, probably through modulating lipid metabolism, reducing inflammation response, and dilating blood vessel. [

关 键 词：不稳定型心绞痛 丙酸睾丸酮 临床研究 治疗 

分 类 号：R541[医药卫生—心血管疾病]