升麻地上部分化学成分研究  

Studies on the chemical constituents of the aerial part of Cimicifuga foetida L.

作　　者：潘瑞乐[1] 陈迪华[1] 斯建勇[1] 赵晓宏[1] 沈连钢[1] 

机构地区：[1]中国医学科学院中国协和医科大学药用植物研究所,北京100094

出　　处：《药学学报》2003年第4期272-275,共4页Acta Pharmaceutica Sinica

摘　　要：目的　为开发中药升麻 (CimicifugafoetidaL .)的地上部分资源 ,从中寻找新的天然活性成分。方法　利用多种色谱技术进行分离纯化 ,根据理化性质和现代波谱技术并辅以化学方法进行结构鉴定。结果　从升麻地上部分 80 %乙醇提取物的乙酸乙酯部分分得 5个 9,19 环菠萝蜜烷型三萜皂苷和 1个甾醇苷。分别鉴定为 :西麻苷I(1) ,西麻苷II(2 ) ,升麻醇半乳糖苷 (3 ) ,12 β 羟基升麻醇木糖苷 (4) ,12 β 羟基升麻醇阿拉伯糖苷 (5 ) ,胡萝卜苷 (6)。 结论1和 2为新化合物 ,4及 5为首次从该植物中分得。Aim To look for new active constituents from the aerial part of Cimicifuga foetida L. Methods Various column chromatographic techniques were used for the isolation and purification of the principles. The structures were elucidated on the basis of spectral data and chemical evidences. Results Five 9,19 cycloartane triterpenoid saponins and one sitosterol saponin were obtained and identified as cimifoetiside I [12β hydroxycimigenol 3 O β D galactoyranoside, (1)], cimifoetiside II [(23 R ,24 R ) cimigenol 3 O β D galactopyranoside, (2)], cimigenol 3 O β D galactopyranoside (3), 12β hydroxycimigenol 3 O β D xylopyranoside (4), 12β hydroxycimigenol 3 O α L arabinopyranoside (5), daucosterol (6). Conclusion Compounds 1 and 2 are new and compounds 4 and 5 were isolated from this plant for the first time.

关 键 词：升麻 地上部分 化学成分 研究 中药 

分 类 号：R284.1[医药卫生—中药学]