聚氰基丙烯酸酯纳米颗粒的红外光谱及相关分析  

The Research on IR and TEM of Polybutylcyanoacrylate Nanoparticles

作　　者：李昕[1] 朱永法[1] 赵梅娟[1] 

机构地区：[1]清华大学化学系,北京100084

出　　处：《光谱学与光谱分析》2003年第2期266-269,共4页Spectroscopy and Spectral Analysis

基　　金：国家自然科学基金(批准号:20071021)

摘　　要：在添加了稳定剂(Dextran)的基础上,采用乳液聚合的方法制备直径200nm左右的聚氰基丙烯酸酯纳米颗粒,利用TEM、IR研究了稳定剂Dextran与聚合物纳米颗粒的结合状态以及稳定剂稳定聚氰基丙烯酸酯的机理。结果表明,每个Dextran分子通过有效的羟基与氰基丙烯酸酯共价连接,导致Dextran与颗粒之间发生不可逆的粘附。Through latex polymerization with stabilizer (Dextran, low fraction), we prepared polybutylcyanoacrylate nanoparticles with a size of approximately 200 nm. The nanoparticle diameter decreases with decreasing stabilitzer concentration. Using TEM and IR we studied the combination state and the mechanism between polybutylcyanoacrylate and Dextran. It was shown that each Dextran molecule could therefore contain several cyanoacrylate polymer moieties covalently linked via any of the available Dextran hydroxyl groups. Anchoring of the cyanoacrylate groups within the nanoparticle matrix would therefore result in an irreversible attachment between the Dextran and the nanoparticle. In this way, Dextran could be incorporated throughout the particle matrix as well as on the surface, producing the biodegradable particle. The results have been interpreted by reference to the accepted theories of steric stabilization and dispersion polymerization, and a model is proposed for the nanoparticle formation in the presence of Dextran.

关 键 词：聚氰基丙烯酸酯 纳米颗粒 红外光谱 药物传输载体 靶向释药制剂 稳定剂 

分 类 号：R944.9[医药卫生—药剂学] O633.14[医药卫生—药学]