损毁和兴奋基底外侧杏仁核对大鼠行为活动的影响  

Effects of destruction and excitation of basolateral amygdaloid nuclei on behavioral activity in rats

作　　者：钟明奎[1] 张瑾[1] 朱国庆[1] 张景行[1] 赵乐章[1] 章功良[1] 

机构地区：[1]安徽医科大学生理教研室,合肥230032

出　　处：《安徽医科大学学报》2003年第1期4-6,共3页Acta Universitatis Medicinalis Anhui

基　　金：安徽省教育厅自然科学基金 (编号:2 0 0 2kj172 );安徽医科大学青年科研基金

摘　　要：目的　研究基底外侧杏仁核 (BLN)在行为活动调节中的作用。方法　运用立体定位技术进行核团内微量注射和核团损毁 ,通过开野实验和强迫游泳实验观察大鼠的行为活动的变化。结果　电损毁和红藻氨酸化学损毁双侧BLN后 ,自发活动减少 ,强迫游泳不动时间增加 ;而用L 谷氨酸兴奋BLN时 ,则引起相反效应 ,使自发活动增加 ,强迫游泳不动时间减少。结论　损毁BLN使行为活动减少 。Objective To study the role of basolateral nuclei of amygdaloid body in regulating behavioral activity. Methods Sterotaxic surgery, microinjection,behavioral test were applied to investigate the behavioral activity of rats. Results Electrical lesions of bilateral BLN decreased locomotor activity and increased immobility time in the forced swimming test. Bilateral microinjection of kainic acid (KA, 0 5 μg) into BLN resulted the same effects. However,unilateral microinjection of L glutamate (L Glu, 0 1 μg) enhanced locomotor activity and shortened immobility time. Conclusion Destruction of BLN causes behavioral activity inhibiting effects;while excitation of BLN promoves behavioral activity.

关 键 词：基底外侧杏仁核 大鼠 行为活动 影响 立体定位技术 核团内微量注射 核团损毁 

分 类 号：R338.26[医药卫生—人体生理学]