A Non-linear Non-ideal Model of Simulated Moving Bed Chromatography for Chiral Separations  

作　　者：卢建刚 

机构地区：[1]National Laboratory of Industrial Control Technology Institute of Industrial Process Control,Zhejiang University

出　　处：《Chinese Journal of Chemical Engineering》2003年第2期234-239,共6页中国化学工程学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.20206027);and the Natural Science Foundation of Zhejiang Province(No.202046).

摘　　要：A non-linear non-ideal model, taking into account non-linear competitive isotherms, axial dispersion, film mass transfer, intraparticle diffusion, and port periodic switching, was developed to simulate the dynamics of simulated moving bed chromatography (SMBC). The model equations were solved by a new efficient numerical technique of orthogonal collocation on finite elements with periodical movement of concentration vector. The simulated SMBC performance is in accordance with the experimental results reported in the literature for separation of l,1'-bi-2-naphthol enantiomers using SMBC. This model is useful for design, operation, optimization and scale-up of non-linear SMBC for chiral separations with significant non-ideal effects, especially for high solute concentration and small intraparticle diffusion coefficient or large chiral stationary phase particle.A non-linear non-ideal model,taking into account non-linear competitive isotherms,axial disperison,film mass transfer,intraparticle diffusion,and port periodic switching,was developed to simulate the dynamics of simulated moving bed chromatography(SMBC),The model equations were solved by a new efficient numerical technique of orthogonal collocation on finite elements with periodical movement of conceantration vector,The simulated SMBC performance is in accordance with the experimental results reported in the literature for separation of 1,1''''''''-bi-2-naphtol enantiomers using SMBC,This model is useful for design,operation ,optimization and scale-up of non-linear SMBC for chiral separations with significant non-ideal effects,especially for high solute concentration and small intraparticle diffusion coefficient or large chiral stationary phase particle.

关 键 词：simulated moving bed chromatography chiral separation non-linear isotherm non-ideal effect DYNAMICS 

分 类 号：O658[理学—分析化学]