聚氨酯表面构建磺铵两性离子结构及其抗血小板粘附性的研究  

Construction of Sulfoammonium Zwitterionic Structure onto Surface of Polyurethane by Hexamethylene Diisocyanate (HDD Spacer for Improving Blood Compatibility

作　　者：袁江[1] 袁幼菱[1] 沈健[1] 林思聪[1] 

机构地区：[1]南京大学表面和界面化学工程技术研究中心,南京210093

出　　处：《高等学校化学学报》2003年第5期916-919,共4页Chemical Journal of Chinese Universities

基　　金：973国家重点基础研究发展规划项目(批准号:G1999064705)资助

摘　　要：通过己二异氰酸酯(HDI)在聚醚氨酯(PU)表面构建磺铵两性离子结构,以改善其不凝血性能,首先用HDI活化PU表面,生成PU-NCO衍生物;然后通过N,N-二甲基乙醇胺(DMEEA)中的—OH和PU表面的—NCO反应生成PU-N(CH_3)_2;最后用丙磺酸内酯(PS)进行开环.生成磺铵两性离子结构,用ATR-IR表征了各步反应,对构建前后材料的抗血小板粘附性能进行了比较,结果表明,磺铵两性离子结构具有优异的抗血小板粘附性。At the molecular level, it is believed that polymers containing zwitterionic structure should be more compatible with blood. The films of polyether-urethane were constructed with sulfoammonium zwitterionic structure by a three-step procedure. In the first step, the film surfaces were treated with hexam-ethylene diisocyanate(HDI) in toluene at 50 'C in the presence of dibutyltin dilaurate(DBTDL) as a catalyst. The extent of the reaction was measured by ATR-IR spectra. A maximum number of NCO groups were obtained in about 90 min reaction. In the second step, the hydroxy groups of N, N-dimethylethylethanolamine (DMEEA) were allowed to react in toluene with surface bound isocyanate groups. In the third step, sulfoammonium zwitterionic structures were constructed onto the surface through the ring-opening reaction between tertiary amine constructed by the second step and 1,3-propane-sultone(PS). The surface was characterized by ATR-IR and XPS, and as anticipated, the sulfoammonium structure was constructed on the PU films. The platelet adhesion test revealed that films attached to sulfoammonium zwitterionic structure showed an excellent anti-platelet adhesion. These good results are due to the interfacial sulfoammonium zwitterionic structure.

关 键 词：聚醚聚氨酯 磺胺两性离子结构 表面改性 抗凝血生物材料 抗血小板粘附性能 

分 类 号：R318.08[医药卫生—生物医学工程]