A Facile Solid Phase Synthesis of 2-Alkylthio-4(1H)-quinolones  

作　　者：唐靖 吴明光 黄宪 

机构地区：[1]Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China [2]Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2003年第5期585-587,共3页中国化学（英文版）

基　　金：ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 0 0 72 0 3 2 )

摘　　要：The resin-bound cyclic malonic acid ester 2 reacted with aryl isothiocyanate and alkyl halides to afford the key intermediate arylthioaminomethylene cyclic malonic ester resin 3. Subsequently, resin 3 proceeded thermal cyclization giving the 2-alkylthio-4(1H)-quinolones in good yields and excellent purities.The resin-bound cyclic malonic acid ester 2 reacted with aryl isothiocyanate and alkyl halides to afford the key intermediate arylthioaminomethylene cyclic malonic ester resin 3. Subsequently, resin 3 proceeded thermal cyclization giving the 2-alkylthio-4(1H)-quinolones in good yields and excellent purities.

关 键 词：solid-phase synthesis resin-bound cyclic malonic acid ester 2-alkylthio-4(1H)-quinolones 

分 类 号：O621.25[理学—有机化学]