调理心肾中药对拟痴呆大鼠脑组织中肾上腺能受体功能的影响  

The effect of Heart- and Kidney- Benefiting Chinese Herbal Medicines on the function of adrenergic receptors in brain tissues of analogue dementia rats

作　　者：宫斌[1] 莫启忠[1] 方军[1] 陈坤华[1] 李伟雄[2] 王菊美[1] 匡兴伟[1] 陈荣[1] 

机构地区：[1]上海中医学院,上海200032 [2]深圳市中医院检验科

出　　处：《核技术》1992年第5期304-308,共5页Nuclear Techniques

摘　　要：电损伤可造成大鼠拟痴呆动物模型。用受体放射性配基结合分析法,观察到:大鼠大脑皮层、海马和小脑组织中α_1受体的B_(max)值显著降低,调理心肾中药和对照西药喜德镇(Hydergin)均可明显提高拟痴呆动物脑组织中α_1受体的B_(max)值,使接近正常对照组。电损伤没有引起大鼠脑组织中的MAO-B活性升高,调理心肾中药和西药对MAO-B活性亦无明显调节作用。Analogue dementia modelof rats was produced by electrolytic lesion of brain. α1 -adrenergic receptors were assayed by radioligand binding assay (RRBA). It was found that Bmax of α1 receptors was decreased obviously in cerebral certex, hippo- campus and cerebellum of analogue dementia rats and was raised obviously by Heart-and Kidney- Benefiting Chinese Herbs as well as by Hydergin.The electrolytic lesion did not change the activity of MAO-B in model rat brains. Neither Heart- and Kidney- Benefiting Chinese Herb Medicines nor Hydergin showed marked effect on brain MAO-B activity of the model rats.

关 键 词：肾上腺能受体 神经递质 

分 类 号：R966[医药卫生—药理学]