^(99m)Tc-MIBI制备反应动力学的研究  

Studies on the kinetics of preparation reaction of ^(99m)Tc-MIBI

作　　者：罗世能[1] 谢敏浩[1] 方平[1] 匡琴芳[1] 冯瑛瑛[1] 国毓智[1] 吴春英[1] 奚月芬[1] 

机构地区：[1]江苏省原子医学研究所,无锡214063

出　　处：《核技术》1992年第5期296-299,共4页Nuclear Techniques

基　　金：国家自然科学基金(3880278)

摘　　要：报道了使用自制的冻干药盒制备^(99m)Tc-MIBI的反应动力学的研究。结果表明,^(99m)Tc-MIBI的制备反应表现为“准一级反应”。温度与反应速度常数k的关系为lnk=-13502.3×T^(-1)+36.8(r=0.9907),反应活化能E_α=0.11(MJ/mol)。使用冻干药盒制备^(99m)Tc-MIBI时,只需在100℃水浴加热3min以上.其标记率可达95％以上。In order to explore the excellent condition for the preparation of 99mTc-MIBI, the kinetics of preparation reaction was studied using MIBI freeze-dried kit. The result obtained has shown that the preparation reaction exhibits a first-order reaction. The relationship between temperature and rate constant (k)can be expressed by the equation: lnk= -13502.3/ T+36.8( r=0.9907). The activation energy Ea is equal to 0.11MJ/mol. In order to make.the labelling yield of 99mTc-MIBI higher than 95%, the reaction time should be longer than 3 min at 100℃.

关 键 词：MIBI 锝标记 反应动力学 

分 类 号：R981.2[医药卫生—药品]