Iodogen法制备[^(125)I]-心得静  

Preparation of ^(125)I-idiopindolol with Iodogen

作　　者：廖埔 陈可靖[1] 李志善[1] 陈灏珠[1] 常逢春 

机构地区：[1]中山医院,上海200032 [2]上海医科大学药学院,上海200032

出　　处：《核技术》1992年第5期300-303,共4页Nuclear Techniques

摘　　要：采用Iodogen法制备[^(125)]-心得静,结果提示此标记法具有操作简便、标记率高(91.50±4.52％)等特点,优于目前采用的氯胺T法。制备的[^(125)I]-心得静与大白鼠肺组织膜蛋白的结合具有饱和性、特异性和可逆性,符合配基与受体结合的规律。The 125I-iodopindolol was prepared with the lodogen or Chloramine-T method. The result suggested that iodination of pindolol with lodogen was more simple and had a higher iodinating rate. The binding of 125I-iodopindolol to membrane protein of rat lung tissue was specific, saturable and reversible.

关 键 词：心得静 碘标记 IODOGEN法 氯胺T 

分 类 号：R972[医药卫生—药品]