氚标记对硝基苯甲酰还原青蒿素的合成  

Synthesis of tritiated 12-(p -nitrobenzoyl) dihydroartemisinine

作　　者：杨建忠[1] 唐国忠[1] 

机构地区：[1]中国科学院上海原子核研究所,上海201800

出　　处：《核技术》1992年第8期510-512,共3页Nuclear Techniques

摘　　要：以青蒿素为起始原料,用钠硼氚还原制得氚标记还原青蒿素,然后与对硝基苯甲酰氯缩合反应,得到氚标记对硝基苯甲酰还原青蒿素粗产品,并经硅胶纸层析分离纯化,获得比活度为0.11TBq/mmol的纯品。Tritiated dihydroartemisinine was obtained by reduction of artemisinine with NaBT4, Then it was reacted with nitrobenzoylchloride. The tritiated product was purified by silica gel loaded paper chromatography. The specific activity was 0. 11TBq/mmol.

关 键 词：硝基苯甲酰 青蒿素 氚 标记化合物 

分 类 号：R978.63[医药卫生—药品]