知母对甲亢小鼠模型心肌β受体更新速率的下调作用  

The effect of Zhimu on the turnover of heart β - adrenoceptors in hyperthyroid mice

作　　者：吕志良[1] 徐建国[1] 易宁育 夏宗勤 

机构地区：[1]上海第二医科大学

出　　处：《核技术》1992年第11期651-655,共5页Nuclear Techniques

基　　金：国家自然科学基金

摘　　要：采用(-)^(125)I-心得静为特异配基的β受体结合分析研究表明,知母可抑制甲亢小鼠模型心肌β受体数的增加。用BAlpM不可逆阻断已存在的β受体后,测定不同时间间隔心肌细胞膜β受体数,计算出各动力学参数。知母可使甲亢小鼠心肌β受体生成速率降低48％;降解速率常数降低35％。知母对生成的抑制超过对降解的抑制,结果使甲亢模型的β受体数显著降低,接近正常值。Radioligand binding assay of receptors with 1251 - iodopindolol revealed that Zhimu can siginificantly inhibit the increase of mouse heart β - adrenoceptors induced by T3. The kinetic parameters were calculated from the data of heart β- adrenoceptor binding sites determined at various periods after irreversible blocking of the preexisting β- adrenoceptors. Zhimu can decrease the production rate and degradation rate constant of hyperthyroid mice by 48 % and 35% respectively. These results indicate that Zhimu can decrease the production rate more potently than the degradation rate of heart β - adrenoceptors in hyperthyroid mice, and hence can make the number,of receptor binding sites approach normal.

关 键 词：Β受体阻断药 知母 甲状腺疾病 

分 类 号：R811.5[医药卫生—放射医学]