自发性高血压大鼠多动性的初步观察  

The first observation of the hyperactivity of spontaneous hypertensive rat

作　　者：徐通[1] 周翊[1] 张璐定[1] 钱燕[1] 沈莉[1] 苏渊[1] Sagvolden T 

机构地区：[1]第二军医大学长征医院儿科,上海200003 [2]挪威奥斯陆大学医学系神经生理室

出　　处：《中国行为医学科学》2003年第1期7-8,共2页Chinese Journal of Behavioral Medical Science

基　　金：挪威国家教育基金 ( 97 170 4 456 )

摘　　要：目的　探究注意缺陷多动障碍 (AD/HD)动物模型自发高血压大鼠 (SHR)的多动性变化。方法　实验在标准Campden连续反应测试箱中进行 ,大鼠禁水 2 2h ,采用长变异间期方案 (变异指数 1 80s) ,分析最后 1 0天稳定曲线的均值。结果　 1 .SHR组大鼠按杠次数显著多于WistarKyoto(WKY)组 (P <0 .0 1 )。 2 .实验过程的三个相同阶段SHR大鼠的按杠次数无明显差异 (P >0 .0 5)。3.SHR组的推门次数明显高于WKY组 (P<0 .0 1 ) ,而获水次数与WKY组无显著差异 (P>0 .0 5)。结论　结果说明SHR大鼠的多动性较WKY大鼠强 。Objective To investigate the hyperactivity of SHR (spontaneous hypertensive rat), the animal model of attention deficit/hyperactivity disorder. Methods The experiment was carried on in the standard Campden instrument operant chambers,and the animal were 22h water deprived. A long Varible Interval Schedule was used and the stable documents of the last ten days were analysed. Results 1.The total responses of SHR were much more than that of WKY (P<0.01). 2.There was no much difference of responses of SHR among the three same segments of the experiment (P>0.05). 3.The numbers of openning the cubicle of SHR were much more than that of WKY (P<0.01), but the difference of numbers of the reinforcement between these two groups was not significant (P>0.05). Conclusion The present results demonstrated that the hyperactivity of SHR was much more obvious than that of the WKY, and it is helpful for the clinical research of ADHD.

关 键 词：运动过度 高血压 发病机理 治疗 注意缺陷多动障碍 小儿 

分 类 号：R544.1[医药卫生—心血管疾病]