新生儿血清EPO水平与孕周、日龄的关系  

THE RELATIONSHIP BETWEEN SERUM EPO GESTATION AGE AND AGE OF DAY IN NEWBORN

作　　者：郑惠童[1] 孙新[1] 高伟玲[1] 刘莎[1] 佘文[1] 邹红梅[1] 黄翠玲[1] 李小晶[1] 

机构地区：[1]广州市妇婴医院儿科,510180

出　　处：《中国小儿血液》2003年第2期55-56,71,共3页China Child Blood

摘　　要：研究不同孕周出生的新生儿脐血及不同日龄静脉血的EPO水平 ,并分析其与贫血的关系 ,分别取 4 9例早产儿与 4 6例足月儿脐静脉血清 1ml;并对其中 1 8例早产儿于生后第 7天、1 4天、2 8天取静脉血清 1ml,对其中 1 7例足月儿于生后第 7天取静脉血 1ml,用ELISA方法检测EPO值 ,结果显示 :( 1 )早产儿与足月儿脐血EPO水平无显著差异 (P >0 0 5)。 ( 2 )足月儿生后第 7天血清EPO与脐血比较有显著差异 (P <0 0 0 1 )。早产儿生后第 7天、1 4天、2 8天EPO值与脐血比较明显降低 ,有极显著差异 (P <0 0 0 1 )。因此 ,初步结论 ,新生儿脐血EPO水平与孕周无关。新生儿生后 7天血中EPO水平迅速下降 ,早产儿下降幅度比足月儿更显著 ,持续下降到生后2 8天无上升趋势 ,早产儿贫血多发生在新生儿早期 ,与此时期血中EPO水平大幅度下降有关 ,故用rhEPO治疗早产儿贫血应早期应用。To investigate cord blood EPO level in newborns of different gestation age and venous EPO level in newborns of different age of day and study the relation with anemia, using 1 ml cord venous serum were taken from 49 premature infants and 46 term infants and 1 ml venous serum were taken from 18 premature infants in the group at day 7,14,28 after birth, and also 1 ml venous serum were taken from 17 term infants at day 7 affer birth EPO were measured by ELISA method Results showed: 1 There was no significant difference between EPO level in premature infants and term infants ( P <0 05) 2 There was significant difference between serum EPO level at day 7 after birth and cord blood level in term infants ( P <0 001) 3 The EPO level of premature infants at day 7,14,28 after birth was obviously lower than cord blood level There was significant difference ( P <0 001) Condusion: cord blood EPO level was most relevant to gestation age The blood EPO level decreased quickly during seren days after birth, which was more obvious in premature infants than in term infants The decrease maintained till day 28 after birth Anemia of premature infants mostly occured in early stage of neonate which was relevant to the decrease to blood EPO level during that period So treating anemia of premature infants by rhEPO should be started in early stage of neonate

关 键 词：新生儿 血清 EPO 孕周 关系 日龄 贫血 

分 类 号：R722.6[医药卫生—儿科]