头孢噻肟钠在多壁碳纳米管修饰电极上的电化学行为及分析应用  

Electrochemical Behaviors of Cefotaxime at a Multi-Wall Carbon Nanotubes Modified Glassy Carbon Electrode and Its Analysis Application

作　　者：吕少仿[1] 费俊杰[2] 

机构地区：[1]孝感学院化学系,湖北孝感432100 [2]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《武汉大学学报（理学版）》2003年第2期157-161,共5页Journal of Wuhan University:Natural Science Edition

基　　金：国家自然科学基金资助项目 ( 60 1710 2 3)

摘　　要：提出了一种多壁碳纳米管化学修饰电极的制备方法 ,研究了头孢噻肟钠在该电极上的电化学行为及其测定 .头孢噻肟钠在多壁碳纳米管修饰电极上于 - 0 .85V处有一灵敏的还原峰 .将多壁碳纳米管修饰电极在 pH2 .2的柠檬酸 磷酸氢二钠缓冲溶液中开路富集 2min后 ,以 10 0mV·s-1的扫描速度从 - 0 .3～ - 1.1V进行阴极化扫描并测定 - 0 .85V处的还原峰电流 .该电流与头孢噻肟钠在 2 .0× 10 -7～ 2 .0× 10 -5mol·L-1浓度范围内呈良好的线性关系 ,检出限达 6.0× 10 -8mol·L-1(信噪比为 3 ) .A sensitive electrochemical method was developed for the determination of cefotaxime at a glassy carbon electrode modified with multi-wall carbon nanotubes (MWNT) film. A sensitive cathodic peak of cefotaxime at the MWNT modified electrode was obtained at around -0.85 V. The experimental parameters, which influence the peak current of cefotaxime, such as the amount of MWNT on the glassy carbon electrode, pH of the solution, accumulation time, and scan rate, were optimized. Under the optimum conditions, the reduction peak current was linearly with the concentration of cefotaxime over the range from 2.0×10 -7 to 2.0×10 -5 mol·L -1, with the detection limit of 6.0 ×10 -8 mol·L -1 at the accumulation time of 2 min.

关 键 词：头孢噻肟钠 化学修饰电极 多壁碳纳米管 电化学行为 Β-内酰胺类抗生素 测定方法 

分 类 号：R978.11[医药卫生—药品] R927.2[医药卫生—药学]