实验动物瘙痒的评价  

The Value of the Itch-associated Responses in Laboratory Animals

作　　者：吴娜[1] 方厚华[1] 

机构地区：[1]军事医学科学院实验动物中心,北京100071

出　　处：《中国比较医学杂志》2003年第2期115-116,共2页Chinese Journal of Comparative Medicine

摘　　要：本文介绍了实验动物对痒刺激的各种反应 ,动物瘙痒反应可被类鸦片拮抗药物纳屈酮抑制。根据对动物受到痒刺激时所表现的行为和一系列的电生理活动进行分析 ,可客观地定量地评价动物瘙痒程度 ,利于抗瘙痒药物的药效作用和作用机制的研究。The itch-associated responses of laboratory animals arisen from external stimulation were introduced in this article. The degrees of responses could be quantitatively evaluated by the analysis of skin nerve activities of laboratory animals and electrophysiologic parameters, which is useful for studying the effect of itch-resistant drugs.

关 键 词：实验动物 瘙痒 痒刺激 反应 类鸦片拮抗药物 纳屈酮 电生理活动 抗瘙痒药物 

分 类 号：Q95－33[生物学—动物学] R986[医药卫生—药品]