大豆黄酮类对去卵巢大鼠性激素、血脂、腹部脂肪的影响  

Effect and Mechanism of Isoflavoniphytoestrogen on Sexual Hormone,Cholesterol, Triglyceride and Abdominal Fat in Ovariectomized Rats

作　　者：戴雨[1] 戴大江[1] 牛建昭[2] 宋颖[1] 王兰芳[1] 

机构地区：[1]中国人民解放军空军总医院核医学科,北京100036 [2]北京中医药大学

出　　处：《中国比较医学杂志》2003年第2期84-86,共3页Chinese Journal of Comparative Medicine

摘　　要：目的　研究大豆异黄酮类对去卵巢大鼠性激素、血脂、腹部脂肪的作用及机理。方法　用大豆异黄酮、金雀异黄酮大剂量、小剂量及雌激素灌肠胃 6周后观察药物对大鼠甘油三脂 (TG)、总胆固醇 (TC)、腹部脂肪及雌二醇 (E2 )、孕酮 (P)、睾酮 (T)、泌乳素 (PRL)、促卵泡生成素 (PSH)、促黄体生成素 (LH)的影响。结果　模型大鼠去卵巢 7周后血清TG( 3 94± 0 2 )、TC( 4 17± 0 2 5 )水平、腹部脂肪重量 ( 15 2 4± 3 95 )、体重指数 (BMI=体重 (g) 身长 (cm) 2 ) ( 0 6 77± 0 0 41)较假手术组增加 (P <0 0 5 )。雌激素 (E2 ) ( 1 2 6± 0 76 )、孕酮 (P) ( 2 8 13± 17)、睾酮 (T)( 0 2 6 7± 0 2 7)较假手术降低 (P <0 0 5 )。服用雌激素、大豆异黄酮、金雀异黄酮组、雌二醇 (E2 )增加 ,腹部脂肪重量下降 ,体重指数、血清TG、TC下降 (P <0 0 5 ) )。结论　大豆异黄酮、金雀异黄酮具有降低去卵巢大鼠腹部脂肪、血清甘油三脂 (TG)、总胆固醇 (TC)的作用。其原因可能是由于能使去卵巢大鼠血清E2 增加。Objective To study the effect and mechanism of isoflavoniphytoestrogen on sexual hormone, total cholesterol(TC), triglyceride(TG) and the abdominal fat in ovariectomized rats. Method Five weeks after operation the rats were given isoflavoniphytoestrogen and genistein. After the rats were killed, TG, TC, estradiol|17β(E 2), progesterone(P), testosterone(T), prolactin(PRL), follicle|stimulating hormone(FSH), luteotropic hormone(LH), abdominal fat were measured. Results Compared with false operation group, E-2, P,T of model group were lower (%P%<0^05). Estradiol|17β level of the rats given estrogen, isoflavoniphytoestrogen or genistein was significantly higher, but the abdominal fat, weight index, TG and TC were significantly lower than model group. Conclusion Isoflavoniphytoestrogen and genistein have effect to reduce TG and TC of blood and the abdominal fat. This effect might be through the changes of estradiol|17β in ovariectomized rats.;

关 键 词：大豆黄酮类 性激素 血脂 腹部脂肪 卵巢 促卵泡生成素 促黄体生成素 孕酮 

分 类 号：R711.75[医药卫生—妇产科学]