盐酸芦氟沙星的荧光光谱分析法研究  

Studies on the Analyzing Method of Rufloxacin Hydrochloride by Spectrofluorimetry

作　　者：颜承农[1] 上官云风[1] 潘祖亭[2] 刘义[2] 高振霆[2] 

机构地区：[1]荆州师范学院化学系,湖北荆州434100 [2]武汉大学化学与分子科学学院,武汉430072

出　　处：《分析科学学报》2003年第2期136-138,共3页Journal of Analytical Science

基　　金：湖北省教育厅重点科技项目 ( No.2 0 0 1 A41 0 0 5 )

摘　　要：研究了 β-环糊精、表面活性剂、缓冲溶液及 p H值、表面活性剂等对芦氟沙星荧光强度的影响。提出了用荧光光谱法测定芦氟沙星含量的新方法。该法操作简便 ,检出限低 ,用于实际样品分析 。It was found that the flourescence intensity of rufloxacin hydrochloride was enhanced in the precense of CTMAB and β CD. A simple and highly sensitive spectrofluorimetric method was proposed. At the range of rufloxacin hydrochloxide of 6.58×10 -8 ～5.0×10 -6 mol/L, the value of the fluorescence intensity appeared good linear relations with the concentrations of RFLX. The relative coefficient was 0.9998 and the RSD was 0.9%. The detective limit was 2.19×10 -9 mol/L.

关 键 词：盐酸芦氟沙星 荧光光谱 分析 氟喹诺酮类药物 药物分析 

分 类 号：R978.1[医药卫生—药品] R917[医药卫生—药学]