Efficient Synthesis of 2-Ethyl-A-ring Analogues of 19-Nor-1α,25-dihydroxy Vitamin D_3  

作　　者：WangQiu-an ZHAOYu-rui 

机构地区：[1]ColllegeofchemistryandChemicalEngineering,HunanUniversity,Changsha410082,P.R.China [2]DepartmentofOrganicChemistry,UniversityofGent,Krijgslaan281S4,B-9000Gent,Belgium

出　　处：《Chemical Research in Chinese Universities》2003年第2期165-173,共9页高等学校化学研究（英文版）

摘　　要：The novel 19 nor l α ,25 dihydroxy vitamin D 3 analogues possessing an ethyl at the 2 position(4 and 5), were synthesized by coupling 25 hydroxy Windaus Grundmann ketone derivative 20 with A ring synthons(15 and 19) respectively. The enantioselective synthesis of substituted bicyclic hexanes structure A ring synthons, started from all cis 3,5 dihydroxy 4 ethyl 1 (methoxycarbonyl)cyclohexane via lipase catalyzd asymmetrization, was demonstrated.The novel 19 nor l α ,25 dihydroxy vitamin D 3 analogues possessing an ethyl at the 2 position(4 and 5), were synthesized by coupling 25 hydroxy Windaus Grundmann ketone derivative 20 with A ring synthons(15 and 19) respectively. The enantioselective synthesis of substituted bicyclic hexanes structure A ring synthons, started from all cis 3,5 dihydroxy 4 ethyl 1 (methoxycarbonyl)cyclohexane via lipase catalyzd asymmetrization, was demonstrated.

关 键 词：Ethyl  19  nor  1  α 25  dihydroxy vitamin D  3 Synthesis Lipase  catalyzed Asymmetrization 

分 类 号：Q564[生物学—生物化学]