模拟测定^(103)Pd放射性支架在血管中的剂量分布  

Simulative study on dose distribution of ^(103) Pd stent in blood vessel

作　　者：苑淑渝[1] 戴光复[1] 徐志勇[1] 孙福印[1] 许书河[2] 马凤武[3] 

机构地区：[1]中国医学科学院,中国协和医科大学放射医学研究所,天津300192 [2]中国原子能科学研究院 [3]天津市卫生防病中心

出　　处：《中华核医学杂志》2003年第2期104-106,共3页Chinese Journal of Nuclear Medicine

基　　金：国家自然科学基金资助项目 (30 1 70 2 33)

摘　　要：目的　测定血管内1 0 3Pd放射性支架的剂量分布。方法　采用肌肉组织等效材料代替血管壁 ,用热释光剂量计模拟测量血管内的剂量分布。结果　当支架活度为 9.8MBq时 ,支架表面累积吸收剂量为 9.8Gy(17d)。1 0 3Pd支架表面的剂量分布随径向距离增加而迅速减少 ,在支架表面径向距离 0 .4mm处 80 %的剂量被血管壁吸收。结论　血管内1 0 3Pd支架对血管周围的器官和组织无明显损害。Objective To evaluate the dose distribution of 103 Pd stent in the blood vessel. Methods Simulative study on dose distribution of endovascular 103 Pd stent was conducted with thermoluminescence dosimeter. The vessel wall was substituted by muscle equivalent material in this simulative study. Results When radioactivity of the study 103 Pd stent was 9.8 MBq the absorbed dose from the stent surface by muscle equivalent material was 9.8 Gy at 17 d (the half life period of 103 Pd). The radioactivity of 103 Pd stent surface rapidly attenuated over the radial distance. 80% of the radioactivity at the area that was radially 0.4 mm apart from the stent surface was absorbed by the simulative blood vessel wall. Conclusion Endovascular 103 Pd stent does not exert significant injury on the surrounding organs or tissues.

关 键 词：冠脉再狭窄 模拟测定 ^103Pd放射性支架 血管 剂量分布 

分 类 号：R817[医药卫生—影像医学与核医学]