呼吸系统产超广谱β-内酰胺酶细菌的临床调查  

Bacteria Producing Extended-spectrum Beta-lactmases in Respiration System:the Clinical Investigation

作　　者：陈旭[1] 李建华[1] 张艳[1] 井玉琦[1] 

机构地区：[1]新疆生产建设兵团医院,新疆乌鲁木齐830002

出　　处：《中华医院感染学杂志》2003年第4期373-374,共2页Chinese Journal of Nosocomiology

摘　　要：目的　探讨医院感染呼吸系统革兰阴性菌产ESBLs菌株 ,监测其耐药性指导临床合理使用抗生素。方法　使用Api半自动细菌监测系统 ,药敏试验按NCCLs最新规则操作。结果　医院感染产ESBLs为 2 0 7%,依次为大肠埃希菌、肺炎克雷伯菌、其他菌也有产酶株 ,对头孢类、氨基糖苷类、磺胺类有广泛耐药 ,对喹诺酮类有较高耐药 ,对亚胺培南均敏感 ,重症病房和老年患者是高发区和高危人群。结论　检测ESBLs菌株 ,能指导临床合理用药 ,防止ESBLs病原菌暴发和流行的必要手段。OBJECTIVE To study the production of Gram-negative bacilli extended-spectrum beta-lactmases in respiratory system nosocomial infection, detect bacterial resistance and direct the appropriate use of antibiotics in clinic. METHODS The survey is based on the analysis of a number of collected nosocomial infection cases related to ESBL-producing Gram-negative bacilli from Jan 2001 to Aug 2002. Bacterial culture was performed with routine method: drug susceptibility test Api was used according NCCLs. RESULTS In this sample, productive rate of ESBLs was 20 7%. The bacteria producing ESBLs were mainly from Escherichia coli, Klebsiella pneumoniae and other bacteria. These bacteria were all resistant to cefoxitin, aminoglycosides, sulfanilamides, quinolones, but susceptible to imipenem. ICU is a high-dangerous area, the elderly is a susceptive group. CONCLUSIONS Detection of ESBLs is good to direct appropriate use of antibiotics. It is a necessary method to prevent the outbreak of ESBLs.

关 键 词：呼吸系统 医院感染 ESBLS 耐药性 监测 超广谱Β-内酰胺酶 细菌 耐药性 

分 类 号：R181.34[医药卫生—流行病学] R978.11[医药卫生—公共卫生与预防医学]