225例真菌感染及耐药性分析  

Drug-resistance of Fungus: A 225 Case Analysis

作　　者：解晓珍[1] 席道友[1] 张中奎[1] 

机构地区：[1]第三军医大学新桥医院,重庆400037

出　　处：《中华医院感染学杂志》2003年第4期380-381,共2页Chinese Journal of Nosocomiology

摘　　要：目的　探讨近年来真菌感染的特点及耐药状况。方法　统计 1999年 12月～ 2 0 0 2年 5月 ,真菌感染 2 2 5例临床标本进行回顾性分析。结果　 2 2 5例共获真菌菌株 2 45株 ,其中混合菌 2 0株 ,占 7.8%;白色念珠菌、无名念珠菌、热带念珠菌为主要感染菌群 ;呼吸、血液、肿瘤、肾内、内分泌及CCU/ICU病区真菌感染率较高 ;益康唑、酮康唑的耐药率占 40 .4%和 37.6 %;两性霉素、制霉菌素、5 氟胞嘧啶为 2 .4%、3.3%、4.1%。结论　真菌感染中以白色念珠菌为主 ,免疫力低下可能是引起真菌感染的主要原因 ,两性霉素、制霉菌素、5 氟胞嘧啶仍保持很高的抗菌活性 ,是治疗真菌感染的有效药物。OBJECTIVE To explore the infective trait of fungus and its drug-resistance condition in recent years.METHODS A total of 225 cases of fungus infection of our hospital during Dec 1999 to May 2002 were reviewed and detected.RESULTS A lot of 245 strains were examined in 225 patients,including 20 mixing infective strains(7 8%). Candida albicans and C. tropicalis were the major fungi with the highest infective rates in respiration ward, blood ward,cancer ward,kidney ward and CCU/ICU ward. The drug-resistance rate of fungus to econazole(ECO) is 40.4%, ketoconazole(KTC) 37.6%, amphotericin B(AMB) only 2.4%, nystatin(NYT) only 3.3%, 5-fluorouracil(5-FC) only 4.1%.CONCLUSIONS C. albicans is still the essential strain in fungus infection. Hypo-immunity may be the main cause of fungus infection. AMS, NY,5-FC are effective in therapy of fungus infection.

关 键 词：真菌感染 耐药性 益康唑 酮康唑 两性霉素 念珠菌 抗生素 

分 类 号：R519[医药卫生—内科学]