更昔洛韦治疗新生儿先天性巨细胞病毒感染的临床研究  

Clinical Investigation on Ganciclovir Applied to Treat Neonatal Congenital CMV Infection

作　　者：陈平洋[1] 谢宗德[1] 王涛[1] 

机构地区：[1]中南大学湘雅二医院儿科,湖南长沙410011

出　　处：《中国医师杂志》2003年第4期502-504,共3页Journal of Chinese Physician

摘　　要：目的　评价更昔洛韦对新生儿先天性巨细胞病毒 (cytomegalovirus ,CMV)感染的治疗效果。方法　选 40例新生儿先天性CMV感染患儿 ,分为更昔洛韦治疗实验组 (n =18)与一般治疗对照组 (n =2 2 ) ,实验组采用更昔洛韦高剂量 (诱导治疗 7 5mg/kg ,每隔 12h静脉滴注 ,连用 14d ;维持治疗 10mg/kg ,1次 /d静脉滴注 ,每周 3d ,维持 2～ 3个月 ) ;对照组使用一般支持对症处理。比较两组治疗前后的临床表现、实验室检查及病毒学结果转归。结果　实验组治疗前后其临床表现、实验室检查及病毒学结果转归均有显著性差异 (P <0 0 5 ) ;实验组治疗后与对照组治疗后各项观察指标亦有显著性差异 (P <0 0 5 ) ;对照组治疗前后各项观察指标无显著性差异 (P >0 0 5 )。结论　早期、高剂量、足疗程更昔洛韦治疗对新生儿先天性CMV感染具有显著的近期临床疗效 ,且副作用少 ,值得临床推广。Objective To evaluate therapeutic effects of ganciclovir on neonatal congenital CMV infection.Methods 40 cases of neonatal congenital CMV infection was divided into experimental group with ganciclovir(n=18) and control group with general treatment(n=22).The patients of experimental group were treated with higher dosage of ganciclovir:induced treatment 7 5mg/kg,intravenous drip every 12 hours,continous using for 14 days,then maintenance treatment,10mg/kg intravenous drip every day,for 3-day every week,maintenance treatment 2～3months.The patients of control group was treated with routine mehtod.Later on clinical situation,laboratory examination and virology result were compared in the two groups.Result There were significantly differences of clinical situation,laboratory examination and virology test result between posttreatment and pretreatment in experimental group(P<0 05);there were also significantly differences of every markers when posttreatment of experimental group was compared with control group(P<0 05);There was no differences between pretreatment and posttreatment in control group(P>0 05).Conclusions Using higher dosage,full course ganciclovir treating neonatal congenital CMV infection have remarkably efficacy in early the disease at the onset,so can be widespread in clinical practice.

关 键 词：新生 婴儿 先天性 CMV感染 更昔洛韦 

分 类 号：R722.1[医药卫生—儿科]