HPLC考察川芎茶调颗粒制备中川芎嗪的动态变化  

Investigate the dynamic change of tetramethylpyrazine in processing of Chuangxiongchatiao Granules

作　　者：桂卉[1] 肖锦仁[1] 邹龙[1] 

机构地区：[1]湖南中医学院药学院,湖南长沙410007

出　　处：《中成药》2003年第4期279-280,共2页Chinese Traditional Patent Medicine

摘　　要：目的 :考察川芎嗪在川芎茶调颗粒剂制备过程中的动态变化。方法 :用HPLC法考察不同的提取、浓缩及干燥方法对川芎嗪的提取率及转移率的影响。结果 :用乙醇回流提取比用水煎煮提取川芎嗪的提取率高 ,用旋转薄膜蒸发仪浓缩比直火浓缩 ,减压浓缩川芎嗪的损失小 ,真空干燥比常压干燥川芎嗪的转移率高。结论 :川芎茶调颗粒剂制备时川芎宜用乙醇提取 。Objective:To investigate the dynamic change of tetramethylpyrazine (TMP) in processing of Chuangxiongchatiao Granules. Methods: To explore the influences of the different extraction, concentration and drying method on the transferring rate of TMP by HPLC. Results: Transferring rate of TMP is higher by alcohol than by water. The loss of TMP in concentrating process is lower by rotating distillation than by direct heating concentration and by reduced pressure concentration. The transferring rate of TMP is higher by reduced pressure desiccation than by ordinary pressure. Conclusion: The better extrating way of Chuangxiong is by alcohol in the processing of Chuangxiongchatiao Granules; the concentrating and drying process should be done at the low temperature and by rapid dry process.

关 键 词：川芎茶调颗粒剂 川芎嗪 动态变化 高效液相色谱法 

分 类 号：R284.2[医药卫生—中药学]