两种急性肾盂肾炎大鼠模型病理形态学比较  

Comparision of Pathological Morphology in Two Rat Model of Acute Pyelonephritis

作　　者：龚学忠[1] 杨践[2] 孟秋[2] 郑平东[2] 何立群[2] 

机构地区：[1]上海中医药大学,2001级博士生上海200032 [2]上海市曙光医院,上海200021

出　　处：《深圳中西医结合杂志》2003年第2期74-77,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：作者采用不结扎单侧输尿管、单纯膀胱内注射一定量 (10 6 /ml、10 8/m1)大肠杆菌OlllB4 的方法 ,成功制备了急性肾盂肾炎大鼠模型 ;并比较了与同期建立的单侧输尿管结扎模型的异同。研究结果发现 ,前种模型病理改变相对较轻 ,不会出现明显化脓灶 ,但急性肾盂炎症过程典型。后种模型均可产生单侧肾实质化脓性病变 ,以 10 8/ml组病变为重 ;常伴有肾小管毁损、并可有肾小球累及 ;10 6 /m1组化脓灶局限 ,未见有肾小球病变。同时 ,前种模型未显示有某一侧肾脏易感性 。Experimental, ascending acute pyelonephritis was produced in mice by injecting 0.5 ml of l0 6/ml and 10 8/ml Escherichia coli O lll B 4 into the urinary bladder via the urethra with or without left ureter's ligation. Results of the research showed the pathological changs of kidneys were light and not purulent in the latter,and its pathological changs without any side preference too. The results also showed the two densities all could induce purulent pathological changs in ligated kidney and the changs of 10 8/ml was more serious, and could be accompanied by derogation of renal tubles and disorder of glomerules.

关 键 词：肾孟肾炎 大鼠 模型 病理学 

分 类 号：R692.3[医药卫生—泌尿科学] R365[医药卫生—外科学]