肝炎肝硬化中医证候特点的多元分析  

Multi-analysis: Characteristics of Traditional Chinese Medical Syndrome of Hepatocirrhosis

作　　者：张琴[1] 刘平[2] 陈惠芬[1] 陈良[1] 曹素华[3] 刘莺[2] 魏建军[2] 方志红[1] 吴定中[1] 

机构地区：[1]上海市传染病医院中西医结合科,上海200083 [2]上海中医药大学 [3]复旦大学上海医学院

出　　处：《中西医结合肝病杂志》2003年第2期69-72,共4页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:运用多元分析的方法探讨肝炎肝硬化中医证候特点。方法:根据肝炎肝硬化的临床特点及中医临床四诊信息采集的要求,设计临床调查表:采用临床流行病学调查的方法,通过对223例肝炎肝硬化患者中医症状、体征、舌、脉等四诊信息,结合临床专业知识及中医临床信息分析提取的思维特点,运用SAS6.11软件对223例病人进行系统聚类和主要成分分析等多元统计学方法,探讨肝炎肝硬化中医证候特点。结果:初步结果显示为3类证型特点:第1类型为湿热内蕴、血瘀阻络、肝脾气虚共134例;第2类型为气阴两虚、气虚重于阴虚,湿热内蕴、湿重于热,兼有血瘀共62例;第3类型为气阴两虚、阴虚重于气虚,瘀热内蕴,兼有湿邪内停共27例。其中第1类型表现为以实证为主兼见虚证,第2类型、第3类型表现为以虚证为主兼见邪实。3类证候特点显示:湿热内蕴、血瘀阻络、气阴两虚为肝炎肝硬化的主要病机。结论:聚类分析及主要成分分析等多元统计方法在较大程度上能体现出肝炎肝硬化中医证候的特点及规律性,肝炎肝硬化3类中医证候特点基本符合临床。Objective: Explore the characteristics of traditional Chinese medical syndrome of hepatocirrhosis by way of multi-analysis. Methods: Design a clinical questionnaire according to the clinical characteristics and the demands of traditional Chinese medical information collection of hepatocirrhosis, by means of clinical epidemiological research, with the four diagnosis methods of clinical information of Chinese medical symptom, physical sign, glossa, and pulse collected from 223 hepatocirrhosis cases, together with the professional knowledge and the way of thinking drawn out of clinical information analysis in traditional Chinese medicine; explore the characteristics of TCM syndrome of hepatocirrhosis by multi-statistical methods such as systematic cluster analysis and principal component analysis. Results: Employing the software SAS6.11 to multi-analysis of systematic cluster analysis and principal component analysis of the 223 cases, which resulted in three categories of syndrome characteristics: Type 1 (134cases): damp heat, blood stasis, deficiency of Qi of both liver and spleen; Type 2 (62cases): deficiency of both Qi and Yin, damp more sever than heat, blood stasis; Type 3 (27cases): deficiency of both Qi and Yin, deficiency of Yin more severe than deficiency of Qi, stasis and heat, and damp stasis. Type 1 mainly manifests asthenia syndrome with sthenia syndrome. Type 2 and Type 3 mainly show sthenia syndrome with asthenia syndrome. Three categories of syndrome characteristics suggest that damp heat, blood stasis, deficiency of both Qi and Yin Were interpretation of the causes of hepatocirrhosis. Conclusion: Basically speaking, multi-statistical methods such as systematic cluster analysis and principal component analysis greatly show the characteristics and regularity of TCM syndrome of hepatocirrhosis, and three categories of syndrome characteristics basically conform to clinical distribution.

关 键 词：肝炎 肝硬化 中医证候特点 临床流行病学 调查 多元分析 中医症状 

分 类 号：R259[医药卫生—中西医结合]