193对自然流产夫妇细胞遗传学分析  

193 natural abortion couples' cytogeuetic analysis

作　　者：李淑芬 孙多伦[2] 闫福云 

机构地区：[1]黑龙江省计划生育科学研究所,150036 [2]佳木斯医学院,154002

出　　处：《中国优生与遗传杂志》2003年第2期35-36,共2页Chinese Journal of Birth Health & Heredity

摘　　要：本文对 193对自然流产夫妇进行了细胞遗传学检查 ,发现染色体异常核型 12例 ,大Y 4例 ,共计 16例。罗伯逊易位 4例 ,相互易位 4例 ,其他结构异常 3例 ,数目异常 1例 ,大Y 4例 ,检出率约占 8 2 9% ,占自然流产率的 5 5 % ,与资料报道的 5 0 %～ 6 0 %相接近。本文论述了自然流产次数与染色异常率的关系。大Y染色体 (Y >18或≥D组 )因有遗传效应 ,本文列入异常率中 ,仅供大家参考。According to the 193 couples'cytogenetic examination in this article,who are all suffered from natural abortion,it is found there are 12 abnormal chromosomal karyotypes and 4 hypernormal Y chromosomes.Totally there are 16 cases They include 4 cases of robertsonian translocation,4 cases of reciprocal translocation,3 cases of strutural abnormality,one case of numerical abnormality and 4 cases of hypernormal Y chromosome The positive rate takes up about 8.29 per cent,which is 55 per cent of natural abortion rate It is close to the data 50～60 per cent which is reported The essay discusses the relationship between times of natural abortion and the rate of chromosomal structural abnormality Because the supernormal Y chromosome(Y>18 or≥D team)has hereditary effect,we put it into abnormal rate,which is for reference only.

关 键 词：自然流产 细胞遗传学 染色体异常 早期流产 稽留流产 反复流产 

分 类 号：R714.21[医药卫生—妇产科学]