盐酸小檗碱-环糊精包合物的体外溶出度研究  

Studies on the Dissolution Rate of Berberine Hydrochloride cyclodextrin Inclusion Compound

作　　者：赵榆林[1] 杨波[1] 杨明惠[2] 

机构地区：[1]昆明理工大学生化学院化工系,昆明650224 [2]大理师范高等专科学校生化系,云南大理671000

出　　处：《云南化工》2003年第2期1-3,共3页Yunnan Chemical Technology

基　　金：云南省教育厅青年基金资助项目 ( 2 0 0 14 2 0 42 ) ;云南省教育厅面上基金资助项目 ( 0 2ZY169)

摘　　要：目的探讨包合技术对中药制剂体外溶出度以及缓释作用的影响。方法选用饱和溶液法生成包合物 ,用DSC证明包合物的生成 ;采用分光光度法 ,考察盐酸小檗碱包合物的体外溶出度和缓释作用。结果 β CD·BH、RM β CD·BH和BH的T50 、Td分别为 5 69.8,740 .2min ;73 .7,10 7.0min和 19.6,2 5 .5min ,包合物的释药数据与t作线性回归方程为 :Y =0 .0 63 9t -0 .473 8,Y =0 .5 5 64t+5 .65 8。结论RM β CD·BH和 β CD·BH的溶出速率明显慢于BH ,具有一定的缓释作用 ,同时RM β CD·BH较β CD·BH具有更好的生物利用度 ;β CD·BH和β CD·BH的体外溶出度与t为一相关性良好的线性方程 ,符合零级释药方程。Berberine hydrochloride cyclodextrin inclusion compound were prepared from saturated solution and proved by DSC. Their dissolution rate in vitro was measured by UV spectrophotometer. Results showed dissolution parameters T 50 and T d of β CD·BH, RM β CD·BH and BH were 569.8, 73.7;19.6,min;740.2?min;107.0 and 25.5 min respectively. The regression equation were Y=0.0639t- 0.4738 andY=0.5564t+ 5.658 for RM β CD·BH and β CD·BH. Their dissolution rates were quicker than that of BH, and the relation with time were linear equation.

关 键 词：盐酸小檗碱 环糊精 包合物 体外溶出度 研究 中药制剂 

分 类 号：TQ461[化学工程—制药化工]