活血明目汤对兔实验性高眼压球结膜微循环的影响  

Effect of Huoxuemingmutang on Microcirculation of Bulbar Conjunctiva in Rabbits with Experimental Intraocular Hypertension

作　　者：李兴英[1] 翟玉梅[1] 康凤英[1] 郝桂兰[1] 王桂初 

机构地区：[1]潍坊医学院附属医院眼科中心,山东潍坊261041 [2]高密市中医院眼科

出　　处：《中国微循环》2003年第2期98-100,共3页Journal of Chinese Microcirculation

基　　金：山东省中医管理局科研基金[鲁卫(1999)34]

摘　　要：目的探讨活血明目汤对兔实验性高眼压眼部微循环的影响。方法32只新西兰大白兔前房内注入a_糜蛋白酶 ,制成高眼压实验动物模型 ,并随机等分为活血明目汤治疗组和高眼压阴性对照组。治疗组以活血明目汤灌胃 ,对照组以生理盐水灌胃 ,于不同时间以WX -PA型微循环检测仪检测球结膜微循环状况 ,光电镜观察小梁细胞病理学变化。结果治疗组用药第10d球结膜微循环明显改善 ,与对照组比较有显著性差异 (P<0.01)。结论活血明目汤可明显改善兔实验性高眼压微循环障碍 ,有效防止小梁细胞变性 ,达到降低眼压及保护视功能的目的。Objective To study the effect of the Chinese traditional medicine Huoxuemingmutang on microcirculation of bulbar conjunctiva in New Zealand rabbits with experimental intraocular hypertenˉsion.Methodsα_chymotrypsin was injected into the anterior chamber of rabbits eyes to induce experimental intraocular hypertension.32rabbits were divided into two groups:the therapeutic group administered with Huoxuemingmutang and the control group given N.S.At different time,the conjunctive microcirculation was measured.Results The disorders of the conjunctive microcirculation in the therapeutic group were improved reˉmarkably after ten days'treatment,the differences between two groups were significent(P<0.01).Conclusions Huoxuemingmutang can prevent the trabecular meshwork in rabbits with experimental intraocular hypertension from degenerating,necrosing and proliferating effectively by improving the systemic or ocular microcirculation.

关 键 词：活血明目汤 兔 实验 高眼压 球结膜微循环 生理盐水 原发性开角型青光眼 

分 类 号：R276.752[医药卫生—中医五官科学] R285.5[医药卫生—中医学]