间尼索地平及尼索地平对离体大鼠心脏缺氧性损伤的保护作用  

PROTECTION EFFECTS OF m—NISOLDIPINE AND NISOLDIPINE AGAINST MYOCARDIAL DAMAGE IN ISOLATED ANOXIC RAT HEART

作　　者：杨小平[1] 傅绍萱[1] 李蕴山[1] 王艳辉[2] 武占军[1] 

机构地区：[1]河北医学院药理教研室 [2]承德医学院中药研究室

出　　处：《河北医学院学报》1992年第2期68-70,共3页

摘　　要：问尼索地平(m-Nis)0.1μmol/L及0.01μmol/L,尼索地平(Nis)0.1μmol/L均能明显减轻持续缺氧引起的Langendorff大鼠心脏冠脉流量减少、心率减慢和心肌收缩力减弱,m-Nis保护缺氧心脏的作用较Nis为强。m-Nis0.1μmol/L和Nis0.1μmol/L二者增加氧合K-H液灌注大鼠心脏冠脉流量的作用无差别,m-Nis的负性频率及负性肌力作用均较Nis为弱。The decreases of coronary flow(CF), heart rate(HR) and myocardial contractile force(MCF) induced by perfusion of the langendorff rat heart with anoxic medium were significantly attenuated by the infusion of m—nisoldipine(m—Nis,0.01,0.1μmol/L) or nisoldipine(Nis 0.1μmol/L), and m—Nis showed protective effect higher than Nis. m—Nis and Nis each 0.1μmol/L were equally effective in increasing CF in the isolated rat heart perfused with oxygenated medium, but the negative inotropic and ehronotropic effects of the former were lower.

关 键 词：间尼索地平 尼索地平 心脏 缺氧 

分 类 号：R965[医药卫生—药理学]