乙型肝炎病毒前S_2蛋白和前S_2抗体检测的临床意义  

CLINICAL SIGNIFICANCE OF THE ASSAY OF HBV PRES2 PROTEIN AND ANTI-PRES2 ANTIBODY

作　　者：全硕[1] 裴琇[1] 王麟士[1] 刘金星[1] 张进贵[1] 尹乃宁[1] 曹鸿缙 

机构地区：[1]河北医学院附属三院传染科

出　　处：《河北医学院学报》1992年第4期202-205,共4页

摘　　要：本文用酶联免疫法(ELISA)对202例各类乙型肝炎病毒(HBV)感染者血清前S2蛋白(PreS2)和前S2抗体(抗PreS2)进行了检测。结果PreS2的阳性率为51.5％(104/202),抗PreS2为6.9％(14/202)。各型HBV感染者,PreS2的标化检出率无明显差异。在HBVDNA阳性组、HBeAg阳性组和PHSAR阳性组PreS2的检出率均明显高于阴性组。抗PreS2在急性乙型肝炎(AVH)恢复期的检出率为55.6％,高于慢性迁延性肝炎(CPH)的10.3％(P<0.005)。动态观察发现抗PreS2在AVH患者多产生于HBsAg、HBVDNA被清除后、抗-HBs产生前,这类患者预后较好。CPH患者抗PreS2的出现则提示HBV复制停止,病情稳定。The sera of 202 patients with different types of HBV infection were assayed for PreS2 proteins(PreS2)and Anti-PreS2 antibody (anti-PreS2) by ELISA. The results showed that PreS2 positive rate was 51.5%(104/202) and anti-PreS2 6.9% (14/202). There was no significant difference for PreS2 positive rate among all kinds of patients. In HBVDNA positive group, HBeAg positive group and PHSAR positive group, PreS2 positive rates were all higher than those in the negative groups respectively. Anti-PreS2 positive rate(55.6%)in the eonvalenseent phase of acute hepatitis (AVH) was much higher than that(10.3%)in chronic persistent hepatitis (CPH) (P<0.005). The follow-up study found that in AVH anti-PreS2 appears earlier than anti-HBs and after the clearance of HBsAg and HBV DNA, and these patients have a good clinical resolution. In CPH anti-PreS2 indicates HBV cease of replication.

关 键 词：前S2蛋白 前S2抗体 乙肝病毒 

分 类 号：R512.620.4[医药卫生—内科学]