中脑导水管周围灰质内脑啡肽对催产素增强电针镇痛的影响  

EFFECT OF MET-ENKEPHALIN ON THE ENHANCEMENT OF ELECTROACUPUNCTURE ANALGESIA INDUCED BY OXYTOCIN IN PERIAQUEDUCTAI GRAY OF RATS

作　　者：刘文彦[1] 王宏[2] 冯学泉[1] 王曙光[1] 张艳霞[1] 

机构地区：[1]济宁医学院生理学教研室 [2]泰山医学院神经生物教研室

出　　处：《济宁医学院学报》2003年第1期8-10,共3页Journal of Jining Medical University

基　　金：山东省自然科学基金资助课题 (No .Q98C0 112 4 )

摘　　要：目的　探讨中脑导水管周围灰质 (PAG)内催产素 (OT)与内源性脑啡肽在电针镇痛中的相互关系。方法　以钾离子透入法引起大鼠甩尾反应的电流强度 (mA)为痛反应的指标 ,观察向PAG内注入OT和抗脑啡肽血清 ,对大鼠电针镇痛效应的影响。结果　PAG内注入抗脑啡肽血清后 ,能明显降低电针镇痛的效应 ;但预先注入抗脑啡肽血清 ,并不能阻断OT增强电针镇痛的作用。Objective To study the effect of oxytocin( OT ) on electroacupuncture analgesia in periaqueductal gray(PAG) and its rel ation to endogenous met-enkephalin. Methods The potassium iontophoresis induced tail-flick was us ed to measure the pain threshold. Results OT administration induced a enhancement of electroacup uncture analgesia.Furthermore,pre-injection of AMEKS in PAG not could weake n analgesia effect of OT. Conclusion These data suggest the enhancement of electroacupun cture analgesia by OT is not dependent upon the met-enkephalin in PAG.

关 键 词：中脑导水管周围灰质 催产素 内源性 脑啡肽 电针镇痛 大鼠 

分 类 号：R971.2[医药卫生—药品] R714.3[医药卫生—药学]