正常妊娠和原因不明习惯性流产者免疫治疗前后血清sHLA-I类抗原变化  

Changing of Serum Soluble HLA Class I Antigens in Normal Pregnant Women and Unexplained Recurrent Spontaneous Abortion Patients before and after Active Immunotherapy

作　　者：裴斌 杨珏琴[2] 姚芳娟[2] 吴乾渝[3] 葛瑜[2] 范丽安[2] 

机构地区：[1]厦门市中心血站,厦门361004 [2]上海第二医科大学上海市免疫学研究所,上海200025 [3]上海市东方医院妇产科,上海200120

出　　处：《生殖与避孕》2003年第2期114-115,122,共3页Reproduction and Contraception

摘　　要：目的 :了解可溶性 HLA- I类抗原在正常妊娠及原因不明习惯性流产 ( RSA)中可能发挥的免疫作用。方法 :用夹心 ELISA法测定正常妊娠及 RSA病人主动免疫治疗前后血清可溶性 HLA- I类抗原的含量。结果 :正常妊娠妇女孕早期 ( <3个月 )血清可溶性 HLA- I类抗原的含量显著高于正常水平 ( P<0 .0 1 ) ,孕末期 ( >9个月 )显著低于正常水平 ( P<0 .0 1 )。RSA病人主动免疫治疗前后血清可溶性 HLA- I类抗原水平未发生显著变化。结论 :血清可溶性 HLA- I类抗原在正常妊娠中的动态变化反映了母体免疫系统受到的调节 ;主动免疫治疗对 RSA病人血清可溶性 HLA-Objective: To explore the immunological function of sHLA I antigens in normal pregnant and unexplained recurrent spontaneous abortion (RSA) patients. Methods: Serum sHLA I antigens were detected with sandwich ELISA. Results: In the early term of normal pregnancy, sHLA I antigens were significantly higher than the normal level, while in the late term of the normal pregnancy it was significantly lower than the normal level. The sHLA I antigens level was not significantly different in the RSA patients before and after active immunotherapy. Conclusion: The maternal immune system was regulated by the sHLA I antigens. Active immunotherapy is unlikely to significantly affect the serum sHLA I antigens level in the RSA patients.

关 键 词：妊娠 流产 习惯性 人类白细胞I类抗原 可溶性 

分 类 号：R714.2[医药卫生—妇产科学]