维可健对急性肝损伤小鼠自由基代谢的影响  

Effects of Weikejian(WKJ)on free-radical metabolism in acute experimental hepatic injury in mice

作　　者：马勇[1] 李怀荆[2] 高庆伟[1] 赵锦成[2] 

机构地区：[1]佳木斯大学第一临床医学院,黑龙江佳木斯154003 [2]佳木斯大学基础医学院,黑龙江佳木斯154007

出　　处：《黑龙江医药科学》2003年第2期40-40,共1页Heilongjiang Medicine and Pharmacy

摘　　要：目的:探讨维可健对四氯化碳(CCl_4)肝损伤小鼠GPT、MDA和SOD的影响。方法:采用腹腔注射四氯化碳(CCl_4)致小鼠急性肝损伤为模型,经光学比色法测量GPT、MDA和SOD活性。结果:维可健能够明显降低CCl_4致急性肝损伤小鼠血清GPT、肝组织MDA含量(P<0.01),提高SOD活性(P<0.05)。结论:维可健对肝损伤具有保护作用。Objective: To study the effects of Weikejian (WKJ)on GPT,MDA and SOD in acute experimental hepatic injury caused by CCl4in mice. Method: We used the model of liver injury by CCl4, and measured the contents of GPT,MDA and SOD by colorimeuic method. Result: Weikejian (WKJ) could significantly decrease the content of serum GPT and hepatic MDA(P <0. 01)and increase the activities of SOD ( P <0. 05). Conclusion: Weikejian (WKJ )has effects on protection of mice injury caused by CCl4.

关 键 词：维可健 急性肝损伤 GPT MDA SOD 小鼠 

分 类 号：R285.5[医药卫生—中药学]