载脂蛋白E单克隆抗体的临床应用——1048例分析  

Clinical application of monoclonal antibodies against humam apolipoprotein E: An analysis of 1048 cases

作　　者：赵明耀[1] 夏辉明[1] 张东升[1] 夏福臻[1] 刘守彦[1] 李颖琰[2] 时松和[2] 

机构地区：[1]河南医科大学病理生理学教研室 [2]河南医科大学卫生统计学教研室

出　　处：《河南医科大学学报》1992年第2期107-109,共3页Journal of Henan Medical University

摘　　要：用单克隆抗体ELISA夹心法(McAb ELISA)测定了1048人血清载脂蛋白E(ApoE)含量。结果表明:冠心病、糖尿病、高血压等患者血清ApoE均高于正常人(P<0.01)。ApoE敏感性分析和指标判别分析表明,ApoE高于TC和TG。ApoE在正常组与TC相关(P<0.05),在冠心病、糖尿病、高血压三个疾病组与TG相关(P<0.01),高脂血症Ⅱ_b、Ⅳ型中ApoE升高率高于Ⅱ_a型。初步结果提示ApoE是反映脂蛋白代谢障碍敏感的指标。McAb ELISA (double antibodies Sandwich) was used to determine the serum apolipoprotein E (Apo E) level in 1 048 cases. The result indicated that the serum Apo E levels in patients with coronary heart disease, diabetes or hypertension were higher than those of normal persons (P<0.01). The analysis of sensitivity index judgement of Apo E indicated that Apo E was also better than total cholesterol(TC)and triglyceride (TG). Apo E was correlated to TC in normal persons (P<0.05) and was correlated to TG in the three patient groups (P<0,01). The increasing rate of Apo E in Ⅱ_b or Ⅳ hyperlipomia was higher than that in Ⅱ_a. The results suggest that Apo E may be the sensitive index in the metabolic disturbance of lipoproteins.

关 键 词：载脂蛋白E 脂质代谢 ELISA 

分 类 号：R589.204[医药卫生—内分泌]