2,4,6-三(芳基氨基)-1,3,5-三嗪衍生物的合成方法和微波效应研究  

Synthesis of 2,4,6-Tri(arylamino)-1,3,5-triazine Derivatives and Microwave Irradiation Effect

作　　者：沙耀武[1] 董玉毅[1] 韩涛[1] 

机构地区：[1]清华大学化学系,北京100084

出　　处：《有机化学》2003年第4期380-383,共4页Chinese Journal of Organic Chemistry

摘　　要：用碳酸氢钠作扑酸剂 ,将芳香胺和氰尿酰氯在 1,4 二氧六环中回流状态下反应合成了 7个 2 ,4,6 三 (芳基氨基 ) 1,3 ,5 三嗪衍生物 ,其中 6个是新化合物 .与已有文献报道的方法相比 ,条件温和 ,易于操作 ,收率高 .所合成化合物的结构通过元素分析 ,FAB MS ,IR确定 .在二氧六环∶DMF为 10∶3 (V∶V)的混合溶剂中 ,研究了在微波照射下和常规加热下反应速率的差异 .结果表明 ,微波加热比常规加热下的反应速率至少高 10倍以上 .Some 2, 4, 6-tri (arylamino)-1, 3, 5-triazine derivatives were synthesized in high yields from 2, 4, 6-trichloro-1., 3, 5-triazine and a little excess of aromatic amines in 1, 4-dioxane using sodium hydrogencarbonate as base. Comparing to literature,. this method is mild and easy for operation and productive. The reaction rate was accelerated by at least ten times under microwave irradiation in comparision with that under common heating. The structures of synthesized compounds were determined by elemental analysis, FAB-MS and IR spectra.

关 键 词：2 4 6-三(芳基氨基)-1 3 5-三嗪 衍生物 1 3 5-三嗪 合成 微波辐射 

分 类 号：O626[理学—有机化学] O621.392[理学—化学]