带噁唑啉衍生物侧链的1,7-二氮-12-冠-4的合成及其应用  

Synthesis of Substituted 1,7-Diaza-12-crown-4 Containing Oxazolines and Its Application

作　　者：王成云[1] 商志才[1] 冷桃花[1] 俞庆森[1] 

机构地区：[1]浙江大学化学系,杭州310027

出　　处：《有机化学》2003年第4期384-386,共3页Chinese Journal of Organic Chemistry

摘　　要：用手性α 氨基醇和原氯乙酸三乙酯作用得到的手性唑啉 2a～ 2c和 1,7 二氮 12 冠 4反应 ,合成了带手性侧链的1,7 二氮 12 冠 4衍生物 1a～ 1c 。New bibracchiral lariat crown ethers 1a～1c were synthesized by treatment of 1,7 diaza 12 crown 4 with chiral oxazolines 2a～2c. 2a～2c were prepared from amino alcohols and triethyl orthochloroacetate. Cu(Ⅱ) complexes of 1a～1c were applied to the asymmetric cyclopropanation of 1,1 diphenyl ethylene with alkyl diazoacetate.

关 键 词：噁唑啉衍生物侧链 1 7-二氮-12-冠-4 合成 应用 铜配合物 重氮醋酸酯 烯烃 不对称环丙烷化反应 

分 类 号：O643.3[理学—物理化学]