甲基强的松龙对狼疮性肾炎患者血浆中PAI-1的影响  

Methylprednisolone's influence on the plasma plasminogen activator inhibitor-1 in lupus nephritis patients

作　　者：张冬梅[1] 顾华[1] 孙广东[1] 苗里宁[1] 刘建东[2] 

机构地区：[1]吉林大学第二医院肾内科,长春130041 [2]大连市中心医院肾内科,大连116033

出　　处：《中国免疫学杂志》2003年第5期355-356,共2页Chinese Journal of Immunology

摘　　要：目的 :研究甲基强的松龙对Ⅳ型狼疮性肾炎 (LN)患者血浆中 1型纤溶酶原激活物抑制物 (PAI 1)的影响。方法 :应用免疫组织化学ELISA方法检测患者血浆中PAI 1含量。结果 :①LN治疗组与对照组比较 (P <0 0 1) ;②LN患者经甲基强的松龙两次冲击治疗后与治疗前分别比较 (P <0 .0 1) ;③甲基强的松龙第二次冲击治疗后 ,与对照组比较无显著性差异 (P >0 0 5 )。结论 :甲基强的松龙通过干扰纤溶酶原激活物 (PA) 纤溶酶系统 ,使LN病人血浆中PAI 1含量明显降低 ,从而发挥治疗作用。Objective:To investigate the effect of methylprednisolone that decrease plasminogen activator inhibitor-1(PAI-1) in plasma through mediating the PA/plasmin system.Methods:Employed immunohistochemical technique-ELISA to determine PAI-1 level in plasma.Results:①PAI-1 in LN patients is significantly higher than that in the control group (P<0.01);②PAI-1 in LN patients dropped in patients treated after two shock of methylprednisolone,compared with the non-treatment group(P<0.01);③After second shock,PAI-1 level in LN patients dropped to the normal level of control,compared with the control group(P>0.05).Conclusion:It is thus proved that methylprednisolone is capable of decreasing PAI-1 in plasma through mediating the PA/plasmin system and two shocks is the minimum for effective cure. [

关 键 词：甲基强的松龙 狼疮性肾炎 血浆 PAI-l 影响 

分 类 号：R593.242[医药卫生—内科学]