铅作业工人肾损害早期指标研究  

Study on the early indices of renal damage in lead exposed workers

作　　者：赵立强[1] 游全程[1] 顾华强[1] 王仁仪[1] 

机构地区：[1]四川大学华西第四医院,四川成都610041

出　　处：《中国工业医学杂志》2003年第2期82-83,86,共3页Chinese Journal of Industrial Medicine

摘　　要：目的　探讨铅作业工人肾脏损害的早期指标及其临床意义。方法　 80名铅作业工人分为铅接触正常组、铅吸收组、慢性轻度铅中毒组 ,并以无铅接触史的 43名健康成人作为对照组。分别测定血铅 (PbB)、尿铅 (PbU)、血红细胞游离原卟啉 (FEP)、尿δ 氨基酮戊酸 (δ ALA)、尿 β2 微球蛋白 ( β2 MG)、尿N 乙酰 β D 氨基葡萄糖苷酶(NAG)、尿视黄醇结合蛋白 (RBP)。结果　铅作业工人PbB、PbU、FEP、δ ALA、NAG、RBP均显著高于对照组 ;β2 MG虽亦高于对照组 ,但差别无显著性。结论　长期职业性铅接触可造成肾功能损害 ,尿NAG。Objective To study the early indices of renal damage in lead workers and its clinical significance.Method 80lead workers were divided into the exposure group,the lead-absorption group and the chronic mild poisoning group,another43persons with-out lead exposure were the controls.The results of PbB,PbU,FEP levels and the urinary contents ofδ-ALA,NAG and RBP were all analyzed.Result The levels the PbB,PbU,FEP,δ-ALA,β 2 -MG,NAG and RBP in lead workers were significantly higher than that of the control,butβ 2 -MG levels had no significant difference.Conclusion Long-term exposure to lead could cause renal function-al damage,and the levels of NAG,RBP might be sensitive indicators for early renal functional damage.

关 键 词：铅作业工人 肾损害 早期指标 铅中毒 血铅 尿铅 血红细胞游离原卟啉 尿Β2-微球蛋白 

分 类 号：R135.11[医药卫生—劳动卫生] R692[医药卫生—公共卫生与预防医学]