胰岛素对糖尿病大鼠代谢紊乱的调节作用  

Regulation Effect of Insulin on Metabolic Dysfunction of Diabetic Rats

作　　者：邵兰[1] 黄晴 苗振川[1] 李清焕[1] 

机构地区：[1]中国科学院动物研究所,北京100080 [2]沈阳卫生防疫站,沈阳110031

出　　处：《动物学杂志》2003年第2期23-27,共5页Chinese Journal of Zoology

基　　金：中国科学院知识创新工程领域前沿项目资助 (No .KSCX3 -IOZ- 0 3)

摘　　要：利用四氧嘧啶建立糖尿病大鼠模型 ,研究了胰岛素对糖尿病大鼠脂肪、蛋白质、自由基代谢紊乱的调节作用及对机体和肝脏氧化损伤的保护作用。结果表明 ,胰岛素 0 5U kg皮下注射 8周 ,能明显抑制糖尿病引起大鼠体重的降低。皮下注射 6周 ,显著提高了血清总蛋白、白蛋白、总胆固醇的水平 ,降低了血清甘油三酯的含量。胰岛素 1U kg皮下注射 9d ,能显著提高血清超氧化物歧化酶、谷胱甘肽过氧化物酶的活性 ,降低血清丙二醛的含量及促氧化酶黄嘌呤氧化酶的活性 ,提高肝线粒体谷胱甘肽过氧化物酶的活性 ,降低肝线粒体丙二醛的含量。从而调节糖尿病大鼠脂肪、蛋白质、自由基代谢紊乱 ,减轻机体的氧化损伤 ,改善肝功能。The objective of this research was to observe the regulatory effects of insulin on lipid,protein and radical metabolic dysfunction,and its Anti|oxidative effect on the liver and body in Diabetic rats.Rats were injected iv with alloxan 40?mg/kg to induce diabetes.Insulin 0^5?U/kg s.c administered daily for 8 weeks obviously increased the body weight of diabetic rats.Insulin 1?U/kg s.c daily for 6 weeks improved the amount of TC,TP,Alb,decreased the amount of TG.Insulin 1?U/kg s.c daily for 9 days improved the activity of T|SOD,GSH|Px,reduced the activity of XOD in the blood serum of diabetes rats,reduced the production of MDA and remarkably improved the activity of GSH|Px in liver mitochondria.So insulin can improve lipid,protein and radical metabolic function and prevent injury from oxidation of the liver and body in diabetes rats.

关 键 词：糖尿病 胰岛素 代谢紊乱 调节作用 四氧嘧啶 动物模型 氧化损伤 保护作用 

分 类 号：R587.1[医药卫生—内分泌] R977.15[医药卫生—内科学]